反应详情

N-[[(2R)-4-Benzylmorpholin-2-yl]methyl]-7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide 15b (370 mg, 0.59 mmol) was dissolved in 30 mL of methanol. The reaction solution was hydrogenated with H-Cube (column of catalyst: 10% palladium/carbon; the pressure of hydrogen: 10 atmosphere; temperature: 40° C.) for 8 hours. The reaction solution was concentrated under reduced pressure to obtain the title compound 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[[(2R)-4-methylmorpholin-2-yl]methyl]-2,3-dihydrobenzofuran-4-carboxamide 15 (60 mg, yield: 18.5%) as a white solid.

1. concentrationThe reaction solution was concentrated under reduced pressure