反应详情

Benzyl N-[(2S)-2-hydroxy-3-(4-methylpiperazin-1-yl)propyl]carbamate 21b (840 mg, 2.70 mmol) was dissolved in 50 mL of methanol to prepare a 0.01 mol/L solution. The reaction solution was hydrogenated with H-Cube (column of catalyst: 10% palladium/carbon; temperature: 30° C.; flow rate: 1 mL/min; pressure: 1 atmosphere) for 50 minutes. The reaction solution was concentrated under reduced pressure to obtain the crude title compound (2S)-1-amino-3-(4-methylpiperazin-1-yl)propan-2-ol 21c (500 mg) as a yellow oil which was used in the next step without further purification.

1. concentrationThe reaction solution was concentrated under reduced pressure