Perfluoro propyl vinyl ether → Dimethyl 5-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)isophthalate

In a dry box, dimethyl 5-hydroxyisophthalate (63.0 g, 0.300 mol) was added to an oven-dried multiple neck reaction flask equipped with a stirring bar and a pressure equaling (PE) addition funnel. Tetrahydrofuran (THF, 1500 mL) was then added to the reaction flask, and the reaction mixture was stirred until a homogeneous solution resulted. Potassium t-butoxide (9.24 g, 0.0825 mol) was added to the reaction mixture, resulting in a heterogeneous mixture. Via the PE funnel, heptafluoropropyltrifluorovinyl ether (199.2 g, 0.075 mol) was added to the reaction flask to form a reaction mixture. The reaction mixture was allowed to stir at room temperature for ˜24 hours. The reaction was quenched by the addition for 80 mL of 10% HCl to the reaction flask to form a reaction material. The resulting material was concentrated at reduced pressure. The material was then dissolved in dichloromethane (˜150 mL) and then washed with 10% HCl (2×100 mL) and then with water (˜100 mL) to form an organic phase and an aqueous phase. The separated organic phase was then dried over anhydrous sodium sulfate. The sodium sulfate was then filtered off and the resulting material containing a crude product was concentrated at reduced pressure. The crude product was purified by column chromatography resulting in 100.87 g (70.63%) yield of the desired material, dimethyl 5-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)isophthalate.

1. customequipped with a stirring bar
2. addition(PE) addition funnel
3. customresulted
4. customresulting in a heterogeneous mixture
5. customto form a reaction mixture
6. stirringto stir at room temperature for ˜24 hours
7. customThe reaction was quenched by the addition for 80 mL of 10% HCl to the reaction flask
8. customto form a reaction material
9. concentrationThe resulting material was concentrated at reduced pressure
10. dissolutionThe material was then dissolved in dichloromethane (˜150 mL)
11. washwashed with 10% HCl (2×100 mL)
12. customwith water (˜100 mL) to form an organic phase
13. dry with materialThe separated organic phase was then dried over anhydrous sodium sulfate
14. filtrationThe sodium sulfate was then filtered off
15. additionthe resulting material containing a crude product
16. concentrationwas concentrated at reduced pressure
17. customThe crude product was purified by column chromatography

ORD record

ord-d12f45eae557419e8cd7dd4b0950136b

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08697831B2