反应详情

A solution of a solution of tert-butyl({4-[6-(cyclopropylmethoxy)-1-benzofuran-2-yl]cyclohexyl}oxy)diphenylsilane (3.36 g) and tetrabutylammonium fluoride in THF (1.0 M, 12.8 mL) in THF (30 mL) was stirred at room temperature overnight and extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (0.66 g).

1. extractionextracted with ethyl acetate and water
2. washThe obtained organic layer was washed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe obtained residue was purified by silica gel chromatography (hexane/ethyl acetate)