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HRID2369541

反应详情

EQUATION

反应方程式

HRID 2369541 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C
HCID7018766

Boc-L-leucinol

C11H23NO3

反应SMILES：FC(F)(F)C1Oc2cc(Cl)ccc2-c2ccncc21
HCID86724440

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(C)C[C@@H](COc1ccc2c(c1)OC(C(F)(F)F)c1cnccc1-2)NC(=O)OC(C)(C)C
HCID86724439

未命名化合物

收率 49%

PROCEDURE

实验过程

Prepared as described in Example 8, Part C using (S)-tert-butyl(1-hydroxy-4-methylpentan-2-yl)carbamate and 8-chloro-5-(trifluoromethyl)-5H-chromeno[3,4-c]pyridine to afford tert-butyl((2S)-4-methyl-1-((5-(trifluoromethyl)-5H-chromeno[3,4-c]pyridin-8-yl)oxy)pentan-2-yl)carbamate (0.28 g, 0.516 mmol, 49% yield) as a yellow solid. LCMS (ESI) m/e 467.2 [(M+H)+, calcd for C24H30F3N2O4 467.2]; LC/MS retention time (Method C): tR=2.19 min.

WORKUP

后处理

  1. customPrepared