反应详情

Anhydrous potassium carbonate (0.204 g, 14.8 mmol), and methyl iodide (0.209 g, 14.8 mmol) were added to a stirred solution of 3,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonamide (0.250 g, 5.94 mmol) in acetonitrile (10 mL) under a nitrogen atmosphere at room temperature. After 2 h, the solvent was removed in vacuo and the residue was partitioned between ethyl acetate and water. The organic phase was dried over anhydrous sodium sulfate, and the solvent was removed in vacuo. The crude reaction mixture was subjected to purification by column chromatography on silica gel. Elution with an ethyl acetate-hexane mixture (20:80) gave 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]-N-(methyl)benzenesulfonamide (0.175 g) as a white colored solid.

1. customthe solvent was removed in vacuo
2. customthe residue was partitioned between ethyl acetate and water
3. dry with materialThe organic phase was dried over anhydrous sodium sulfate
4. customthe solvent was removed in vacuo
5. customThe crude reaction mixture
6. customwas subjected to purification by column chromatography on silica gel
7. washElution with an ethyl acetate-hexane mixture (20:80)