反应详情

温度

-60 °C

11.05 g 2,4-Lutidine (0.1 mol) were dissolved in 50 ml THF. The solution was cooled and stirred, maintaining the temperature at between −70 to −50° C. 81.25 ml nBuLi (0.13 mol) was added over 0.25 hour. The dark red solution was stirred for a further 0.5 hour, then 15.14 ml diethylamine (0.145 mol) was added in one portion producing an orange suspension. After a 0.5 hour, 15.5 ml DMF (0.2 mol) was added. The brown-red solution was stirred for 1 hour then quenched with 50 ml 50% saturated aqueous ammonium chloride solution. Upon warming to ambient temperature, the reaction mixture was extracted with tert. butyl methyl ether (TBME) (3×100 ml), and the combined organic phases were washed with 50 ml H2O, dried over Na2SO4, filtered and concentrated under reduced pressure (45° C./450-20 mbar) providing an orange-red oil (14.8 g, 91%) which was sufficiently pure (Gas Liquid Chromatography (GLC) 98 area %) to be used directly in the next step.

1. temperatureThe solution was cooled
2. stirringThe dark red solution was stirred for a further 0.5 hour
3. customproducing an orange suspension
4. stirringThe brown-red solution was stirred for 1 hour
5. customthen quenched with 50 ml 50% saturated aqueous ammonium chloride solution
6. temperatureUpon warming to ambient temperature
7. extractionthe reaction mixture was extracted with tert. butyl methyl ether (TBME) (3×100 ml)
8. washthe combined organic phases were washed with 50 ml H2O
9. dry with materialdried over Na2SO4
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure (45° C./450-20 mbar)