HCID 69205100, compound → HCID 86597136, compound

HRID 2373787Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][CH:17]([NH2:24])[C:18]3[O:22][N:21]=[C:20]([CH3:23])[N:19]=3)[CH:11]=2)[CH:6]=[CH:7][C:8]=1[F:9].[Cl:25][C:26]1[C:27]([O:45][CH3:46])=[C:28]([C:42](O)=[O:43])[CH:29]=[C:30]([C:32]2[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=2)[CH:31]=1>>[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][C@@H:17]([NH:24][C:42]([C:28]3[CH:29]=[C:30]([C:32]4[CH:33]=[CH:34][C:35]([C:38]([F:40])([F:41])[F:39])=[CH:36][CH:37]=4)[CH:31]=[C:26]([Cl:25])[C:27]=3[O:45][CH3:46])=[O:43])[C:18]3[O:22][N:21]=[C:20]([CH3:23])[N:19]=3)[CH:11]=2)[CH:6]=[CH:7][C:8]=1[F:9]

Participants

Reactant 2

HCID 69205100HCID 69205100, compound

HCID 69207124HCID 69207124, compound

Product 1

HCID 86597136HCID 86597136, compound

Procedure

5-Chloro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-3-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (0.087) was prepared using the general procedure A, from 2-(3′-Chloro-4′-fluoro-biphenyl-3-yl)-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine hydrochloride salt (0.077 g, 0.21 mmol, prepared from [2-(3′-Chloro-4′-fluoro-biphenyl-3-yl)-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamic acid tert-butylester following general procedure N) and 5-Chloro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (0.07 g, 0.21 mmol).

Sources & evidence

ORD record: ord-f243b98eec9f4b3a8615b367dc75c392
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

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