反应详情

5-Chloro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-[4-(3-chloro-4-fluoro-phenoxy)-phenyl]-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (0.07 g) was prepared from 2-[4-(3-Chloro-4-fluoro-phenoxy)-phenyl]-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine hydrochloride [0.07 g, 0.182 mmol, which was prepared from [2-[4-(3-Chloro-4-fluoro-phenoxy)-phenyl]-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamic acid tert-butyl ester by the hydrolysis of BOC group using the general procedure N] and 5-Chloro 4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (as in example 42) (0.053 g, 0.18 mmol) following general procedure A. 5-Chloro-4-hydroxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-[4-(3-chloro-4-fluoro-phenoxy)-phenyl]-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (20 mg) was obtained upon methyl ether hydrolysis using the general procedure P. 1HNMR (400 MHz, CDCl3): 2.40 (s, 3H), 3.39 (m, 2H), 5.79 (dd, 1H), 6.84 (m, 1H), 6.90 (d, 2H), 7.02 (1 H), 7.04-7.17 (m, 4H), 7.50 (d, 1H), 7.61 (d, 2H), 7.71 (d, 2H), 7.78 (d, 1H), 12.03 (s, 1H).