HRID2373795
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 0 °C
PROCEDURE
实验过程
2-(S)-[(3′-Chloro-4′-fluoro-4-hydroxy-biphenyl-3-carbonyl)-amino]-3-(3′-trifluoromethyl-biphenyl-4-yl)-propionic acid methyl ester (3.0 g, 5.2 mmol) was dissolved in 100 mL of THF-methanol (4-1), cooled to 0° C. and 20 mL 2N LiOH added. The reaction was stirred at 0° C. for 1 hour. Ethyl acetate (100 mL) and 1N HCl (100 mL) were added to the mixture and the organic washed with brine, dried and evaporated to give 2-(S)-[(3′-chloro-4′-fluoro-4-hydroxy-biphenyl-3-carbonyl)-amino]-3-(3′-trifluoromethyl-biphenyl-4-yl)-propionic acid (2.8 g). LC/MS (m/z): 558 [(M+1)+].
WORKUP
后处理
- washthe organic washed with brine
- customdried
- customevaporated