反应详情

In a similar manner as described for Example 9, 3-bromo-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)thiophene-2-carboxamide (Intermediate 19) (0.23 g, 0.47 mmol) and 1,2,4-triazole (100 mg, 1.5 mmol) in pyridine (4 mL) and phosphorus oxychloride (0.070 mL, 0.75 mmol) gave 7-(3-bromothien-2-yl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (0.033 g) as a yellow solid. 1H NMR (CDCl3): δ8.82 (s, 1H), 7.47 (d, J=5.3 Hz, 1H), 7.13 (s, 1H), 7.10 (d, J=5.3 Hz, 1H), 6.89 (s, 2H), 3.80 (s, 3H), 3.75 (s, 6H), 2.63 (s, 3H). MS m/z 476, 478 (M+1, M+3).