反应详情

2-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propionic acid (500 mg) is dissolved in 10 mL of tetrahydrofurane, 1,1′-carbonyldimidazole (217 mg) and 30% ammonium hydroxide water solution are added and the reaction mixture is stirred at room temperature for 3 h. The reaction mixture is concentrated under vacuum, ethyl acetate is added and the organic solution is washed with a 10% HCl water solution. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give the title compound. Yield: 300 mg.

1. concentrationThe reaction mixture is concentrated under vacuum, ethyl acetate
2. additionis added
3. washthe organic solution is washed with a 10% HCl water solution
4. customThe organic phase is separated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under vacuum