反应详情

4-{1-[3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenol (obtained as described in Example 5.2, preparation of starting materials) (30 g, 82.57 mmol) and 5% Pd on carbon (50% wet, JM Type 87L) (35.1 g, 8.26 mmol) in MeOH (50 mL) were stirred under an atmosphere of hydrogen at 5 bar and 50° C. for 5 days. The mixture was cooled to room temperature and the catalyst removed by filtration. The solvent was evaporated to give 4-{1-[3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenol (20.54 g, 68%).

1. customthe catalyst removed by filtration
2. customThe solvent was evaporated