反应详情

Using the method described in Example 78, Step 3,3-cyclopentyl-2-(6-oxo-6H-pyridazin-1-yl)-propionic acid (prepared as in Example 78, Step 2) and thiazol-2-ylamine afforded 3-cyclopentyl-2-(6-oxo-6H-pyridazin-1-yl)-N-thiazol-2-yl-propionamide as a white solid (39.9 mg, 29%); ES+-HRMS m/e calcd for C15H18N4O2S [M+H+] 319.1223 found 319.1223. 1H-NMR (300 MHz, DMSO-d6) δ ppm 1.00-1.75 (m, 9H), 1.99 (m, 1H, CH), 2.28 (m, 1H), 5.60 (dd, J=4.5, J=10.3 Hz, 1H), 6.98 (dd, Jo=9.4 Hz, Jm=1.5 Hz, 1H), 7.23 (d, J=3.6 Hz, 1H), 7.45 (dd, Jo=9.4, Jo=3.6 Hz, 1H), 7.49 (d, J=3.6 Hz, 1H), 8.02 (dd, Jo=3.6 Hz, Jm=1.5 Hz, 1H), 12.58 (s, 1H).