反应详情

Using the method described in Example 78, Step 3, from 3-cyclopentyl-2-(6-oxo-6H-pyridazin-1-yl)-propionic acid (As prepared in Example 78, Step 2) and 1-methyl-1H-pyrazol-3-ylamine afforded 3-cyclopentyl-N-(1-methyl-1H-pyrazol-3-yl)-2-(6-oxo-6H-pyridazin-1-yl)-propionamide as a white solid (37.1 mg, 36%); ES+-HRMS m/e calcd for C16H21N5O2 [M+H+] 316.1768 found 316.1768. 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.07 (br s, 1H), 1.24-1.36 (m, 1H), 1.36-1.49 (m, 2H), 1.49-1.74 (m, 5H), 1.93 (ddd, J=13.4, 8.6, 4.5 Hz, 1H), 2.18-2.31 (m, 1H), 3.73 (s, 3H), 5.51 (dd, J=10.7, 4.7 Hz, 1H), 6.35 (d, J=2.0 Hz, 1H), 6.94 (dd, J=9.5, 1.5 Hz, 1H), 7.42 (dd, J=9.5, 3.7 Hz, 1H), 7.53 (d, J=2.0 Hz, 1H), 7.99 (dd, J=3.7, 1.5 Hz, 1H), 10.72 (s, 1H).