3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 25212520, compound

HRID 2382781Notes

Reaction equation

HRID 2382781 reaction equation
[Cl:1][C:2]1[N:7]2[N:8]=[C:9]([NH2:11])[N:10]=[C:6]2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.Cl.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[N:20][CH:19]=1>>[Cl:1][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[N:20][CH:19]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:12]([F:13])([F:15])[F:14])[CH:3]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 252161845-Chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25212520HCID 25212520, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A7), 2.72 g; 11.5 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (2.46 g; 13.8 mmol; 1.2 eq.) as a greenish solid (1.42 g; 36%). HPLC, Rt: 2.16 min. (purity 100%). LC/MS, M+(ESI): 342.2, M−(ESI): 340.2.

Sources & evidence

ORD record
ord-23ff3f60910e4f31b92ea456cf9149f2
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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