Cyclooctylamine → N-[5-(cyclooctylamino)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide

HRID 2382848Notes

Reaction equation

HRID 2382848 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:20]1([NH2:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH:20]1([NH:28][C:2]2[N:7]3[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=4)[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 2903CyclooctylamineHCID 25212516N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

Product 1

HCID 25214209N-[5-(cyclooctylamino)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide

Procedure

The title compound was prepared following procedure described for example 30 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide ((B4), 58 mg; 0.21 mmol; 1.0 eq.) and cyclooctylamine (440 μL) as a white powder (4 mg, 4%). HPLC, Rt: 3.25 min. (purity 97.9%). LC/MS, M+(ESI): 365.4, M−(ESI): 363.4.

Sources & evidence

ORD record
ord-112d64c07966418898f56453600f9170
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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