反应详情

To a solution of 1,1-dimethylethyl 1-[2-(butyloxy)-2-oxoethyl]-6-cyano-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate (Preparation 18; 2.15 g, 5.56 mmol) in ethanol (10 ml) and diethyl ether (40 ml) was added lithium borohydride (2M solution in tetrahydrofuran, 4.17 ml; 8.34 mmol) at 25° C. under nitrogen. After 1.5 h at 25° C., the solvent was removed, and the residue dissolved in ethyl acetate. The solution was washed with 1N hydrochloric acid, and the aqueous layer further extracted with ethyl acetate. The combined organic phases were washed with saturated sodium bicarbonate, dried over MgSO4 and concentrated in vacuo to give the title compound (1.70 g) as a white foam.

1. customthe solvent was removed
2. dissolutionthe residue dissolved in ethyl acetate
3. washThe solution was washed with 1N hydrochloric acid
4. extractionthe aqueous layer further extracted with ethyl acetate
5. washThe combined organic phases were washed with saturated sodium bicarbonate
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo