反应详情

Ethanol (1 ml) and 2M sodium hydroxide (1 ml) were added to 1,1-dimethylethyl 6-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-1-[4-(ethyloxy)-4-oxobutyl]-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate (Preparation 30; 100 mg, 0.17 mmol) and the mixture stirred at room temperature for 3 hours. The ethanol was evaporated and the residue acidified with glacial acetic acid. The mixture was extracted with ethyl acetate (2×2 ml). The combined extracts were dried and evaporated. The residue was triturated with iso-hexane to give the title compound (51 mg) as a colourless glassy solid.

1. customThe ethanol was evaporated
2. extractionThe mixture was extracted with ethyl acetate (2×2 ml)
3. customThe combined extracts were dried
4. customevaporated
5. customThe residue was triturated with iso-hexane