反应详情

A 0.5M solution of cyclopropyl magnesium bromide in THF (2.4 mL, 1.170 mmol) was added dropwise to 2-fluoro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzaldehyde (I-121a: 175 mg, 0.585 mmol) in dry THF (10 mL) at 0° C. under nitrogen atmosphere. The resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was quenched with aqueous NH4Cl solution and the THF layer was concentrated. The aqueous layer was extracted with ethylacetate. The organic layer was dried over Na2SO4 and concentrated to afford the crude product. Purification by column chromatography on silica gel (3% MeOH in CHCl3), followed by hexane wash, afforded 200 mg of the product (99.41% yield).

1. customThe reaction mixture was quenched with aqueous NH4Cl solution
2. concentrationthe THF layer was concentrated
3. extractionThe aqueous layer was extracted with ethylacetate
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated
6. customto afford the crude product
7. customPurification by column chromatography on silica gel (3% MeOH in CHCl3)
8. washwash