反应详情

Methylamine, generated by heating a mixture of methylamine hydrochloride (10 g) and sodium hydroxide pellets (18 g), was condensed (dry ice trap) into a solution of 4,4-dimethylcyclohexanone (1.0 g, 7.9 mmol) in 40 ml of methanol and 20 ml of THF. 10% Pd on C (400 mg) was added and the mix was hydrogenated at room temperature over night. The solids were filtered off, and the mixture concentrated under vacuum. This material and triethylamine (2 ml) were dissolved in chloroform (50 ml) and a solution of [2,1,3]-benzoxadiazole-5-carbonylchloride (900 mg, 4.9 mmol), in chloroform (40 ml), was added slowly at room temperature. After stirring the mixture for 1 hour, the organic phase was washed with 1N HCl and cone. NaHCO3 solution, dried over sodium sulfate, and concentrated under vacuum to yield an oil, which was purified using silica gel chromatography eluting with chloroform/ethyl acetate/hexane (10:20:70), to give a white solid, after crystallization from methyl-t-butyl ether (MTBE)/hexane (38 mg). Mp=143-5° C., 1H NMR (300 MHz, CDCl3, rotamers) δ 7.91 (d, 1H, J=8.7 Hz); 7.81 (sb, 1H); 7.45-7.36 (m, 1H); 4.52-4.35 and 3.45-3.30 (m+m, 1H); 3.04 and 2.89 (s+s, 3H) and 1.95-0.80 ppm (m, 14H).

1. temperatureby heating
2. waitthe mix was hydrogenated at room temperature over night
3. filtrationThe solids were filtered off
4. concentrationthe mixture concentrated under vacuum
5. dissolutionThis material and triethylamine (2 ml) were dissolved in chloroform (50 ml)
6. washthe organic phase was washed with 1N HCl and cone
7. dry with materialNaHCO3 solution, dried over sodium sulfate
8. concentrationconcentrated under vacuum
9. customto yield an oil, which
10. customwas purified
11. washeluting with chloroform/ethyl acetate/hexane (10:20:70)
12. customto give a white solid
13. customafter crystallization from methyl-t-butyl ether (MTBE)/hexane (38 mg)