反应详情

温度

85 °C

4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile (763 mg, 3.76 mmol) was mixed together with (R)-2-amino-3-hydroxy-3-methylbutanoic acid (500 mg, 3.76 mmol) in DMSO (25 mL). K2CO3 (1.56 g, 11.28 mmol) was added to the reaction mixture and the reaction mixture stirred at 85° C. for 18 h. The reaction mixture was allowed to cool to room temperature, quenched with H2O (25 mL) and extracted with EtOAc (2×30 mL). The aqueous layer was then acidified with solid citric acid and extracted with EtOAc (2×80 mL). The later organic extracts were combined, washed with H2O (2×30 mL), dried (Na2SO4), filtered and concentrated under reduced pressure to provided the title compound as a yellow solid (1.15 g, 97%): 1H NMR (400 MHz, d6-acetone, δ in ppm) 7.63 (d, J=9 Hz, 1H), 6.97 (d, J=9 Hz, 1H), 5.62 (d, J=9 Hz, 1H), 4.20 (d, J=9 Hz, 1H), 2.33 (s, 3H), 1.43 (s, 3H) and 1.42 (s, 3H).

1. temperatureto cool to room temperature
2. customquenched with H2O (25 mL)
3. extractionextracted with EtOAc (2×30 mL)
4. extractionextracted with EtOAc (2×80 mL)
5. washwashed with H2O (2×30 mL)
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure