反应详情

温度

100 °C

A sealed tube containing (6-fluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester (49 mg, 0.21 mmol), 1-ethanesulfonyl-4-fluoro-benzene (87 mg, 0.427 mmol), and potassium carbonate (73 mg, 0.53 mmol) was evacuated and filled with nitrogen. Anhydrous N,N-dimethylformamide (2 mL) was added. After being stirred at 100° C. overnight, the mixture was cooled to room temperature, then diluted with water (10 mL), and extracted with ethyl acetate (10 mL×2). The combined organic layers were washed with brine (10 mL×3), dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography (elution with 30% ethyl acetate in petroleum ether) to give [4-(4-ethanesulfonyl-phenoxy)-6-fluoro-naphthalen-2-yl]-acetic acid methyl ester (67.6 mg, 80%) as a white solid.

1. customwas evacuated
2. additionfilled with nitrogen
3. additionAnhydrous N,N-dimethylformamide (2 mL) was added
4. temperaturethe mixture was cooled to room temperature
5. additiondiluted with water (10 mL)
6. extractionextracted with ethyl acetate (10 mL×2)
7. washThe combined organic layers were washed with brine (10 mL×3)
8. dry with materialdried over sodium sulfate
9. concentrationconcentrated in vacuo
10. customThe residue was purified by column chromatography (elution with 30% ethyl acetate in petroleum ether)