反应详情

温度

70 °C

A mixture of (1,6-difluoro-4-hydroxy-naphthalen-2-yl)acetic acid methyl ester (50 mg, 0.198 mmol), 2-bromo-5-methanesulfonyl-pyridin (52 mg, 0.22 mmol), potassium carbonate (60 mg, 0.434 mmol) and N,N-dimethylformamide (2.0 mL) was heated at 70° C. for 3 hours. The resulting mixture was cooled to room temperature, acidified with 1 N hydrochloric acid to pH 3, and extracted with ethyl acetate (20 mL×3). The combined organic layers were washed with brine (20 mL×3), dried over sodium sulfate, and concentrated in vacuo to afford [1,6-difluoro-4-(5-methanesulfonyl-pyridin-2-yloxy)-naphthalen-2-yl]-acetic acid methyl ester (70 mg, 87%) as a white solid which was used in the next step without further purification.

1. temperatureThe resulting mixture was cooled to room temperature
2. extractionextracted with ethyl acetate (20 mL×3)
3. washThe combined organic layers were washed with brine (20 mL×3)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo