反应详情

(Z)-5-{2-hydroxy-3-[N′-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-phenyl}-furan-2-carboxylic acid 16a (150 mg, 0.38 mmol) was suspended in 5 mL of tetrahydrofuran to form a dark red suspension. The reaction mixture was added dropwise with diethylamine (49 mg, 0.67 mmol) to form a purple solution, and stirred for 2 hours at room temperature. The solid was precipitated from solution, filtered, then the filter cake was washed with tetrahydrofuran (1 mL×3) and dired in vacuo to obtain the title compound (Z)-5-{2-hydroxy-3-[N′-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-phenyl}-furan-2-carboxylic acid bis-(diethylamine) 17 (163 mg, yield: 81.9%) as a dark red solid.

1. customto form a dark red suspension
2. customto form a purple solution
3. customThe solid was precipitated from solution
4. filtrationfiltered
5. washthe filter cake was washed with tetrahydrofuran (1 mL×3) and dired in vacuo