反应详情

A mixture of (5-{Hydroxy-[5-(2-morpholin-4-yl-ethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]-methyl}-pyridin-2-yl)-(4-trifluoromethyl-benzyl)-carbamic acid tert-butyl ester (24, 0.2 g, 0.3 mmol), triethylsilane (4 mL, 0.02 mol), and trifluoroacetic acid (2 mL, 0.02 mol) in acetonitrile (30 mL) was refluxed for 2 hours. After removal of solvent, the residue was dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine, and dried over magnesium sulfate. After removal of solvent, the residue was purified by silica gel column chromatography eluting with methanol in dichloromethane to provide the compound as a light yellow solid (25, 17 mg, 10%). MS (ESI) [M+H+]+=512.42.

1. temperaturewas refluxed for 2 hours
2. customAfter removal of solvent
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with saturated sodium bicarbonate, brine
5. dry with materialdried over magnesium sulfate
6. customAfter removal of solvent
7. customthe residue was purified by silica gel column chromatography
8. washeluting with methanol in dichloromethane