HRID2388848

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4148881

Lithium borohydride

BH4Li

结构：CCOC(=O)[C@@H](C)Oc1cc(NS(=O)(=O)c2cn(C)c(C)n2)nc(SCc2cccc(F)c2F)n1

HCID53628392

未命名化合物

PRODUCTS

生成物

HCID21882825

未命名化合物

结构：Cc1nc(S(=O)(=O)Nc2cc(O[C@H](C)CO)nc(SCc3cccc(F)c3F)n2)cn1C

HCID59558844

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound was prepared according to the procedure outlined in example 11 using a mixture of ethyl (2R)-2-[(2-[(2,3-difluorobenzyl)thio]-6-([(1,2-dimethyl-1H-imidazol-4-yl)sulfonyl]amino}pyrimidin-4-yl)oxy]propanoate (the product from step (i) (0.25 g), lithium borohydride (2 M solution in THF, 0.48 mL) and THF (6 mL). Purification was by reverse phase HPLC (symmetry as the stationary phase and TFA/acetonitrile as the mobile phase) then titurated with Toluene, DCM and then Et2O/iso-hexane to give the title compound as a white solid. Yield: 44 mg

WORKUP

后处理

customThe title compound was prepared
customPurification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67ef038e24f94121bca84d9ee6471f60
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08269002B2
来源说明: uspto-grants-2012_09

反应 SMILES

[F:1][C:2]1[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([O:12][C@H:13]([CH3:19])[C:14](OCC)=[O:15])[CH:9]=[C:8]([NH:20][S:21]([C:24]2[N:25]=[C:26]([CH3:30])[N:27]([CH3:29])[CH:28]=2)(=[O:23])=[O:22])[N:7]=1.[BH4-].[Li+]>C1COCC1>[CH3:9][CH2:10][O:12][CH2:13][CH3:14].[CH3:33][CH2:34][CH2:2][CH:3]([CH3:31])[CH3:4].[F:1][C:2]1[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:3]=1[CH2:4][S:5][C:6]1[N:7]=[C:8]([NH:20][S:21]([C:24]2[N:25]=[C:26]([CH3:30])[N:27]([CH3:29])[CH:28]=2)(=[O:23])=[O:22])[CH:9]=[C:10]([O:12][C@H:13]([CH3:19])[CH2:14][OH:15])[N:11]=1