反应详情

(R)-2-Amino-2-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propan-1-ol was synthesized as per (R)-2-amino-2-[6-(cis-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propan-1-ol (Example 259) in 83% yield using (R)-4-Methyl-4-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-oxazolidin-2-one as the starting material. MS: m/z=351.20 [M-NH2]+. 1H NMR (400 MHz, METHANOL-d4) δ ppm: 7.86 (d, J=2.0 Hz, 1H), 7.73-7.80 (m, 2H), 7.57 (dd, J=8.8, 2.0 Hz, 1H), 7.26 (d, J=2.5 Hz, 1H), 7.12 (dd, J=8.9, 2.4 Hz, 1H), 4.39-4.49 (m, 1H), 3.74 (d, J=11.0 Hz, 1H), 3.67-3.72 (m, 1H), 2.29-2.38 (m, 2H), 2.19-2.30 (m, 1H), 2.03-2.11 (m, 2H), 1.46-1.66 (m, 7H).