反应详情

13 mg of tert-butyl benzyl[2-[3-benzyl-6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl]ethyl]carbamate was dissolved in 0.5 mL of a 4N hydrochloric acid-ethyl acetate solution, followed by continuously stirring at room temperature for 30 minutes. The reaction liquid was concentrated under reduced pressure, dissolved in ethyl acetate, washed with an aqueous sodium bicarbonate solution and saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue obtained was purified using silica gel chromatography (chloroform:methanol=10:1) to obtain 10 mg (yield 99%) of a title compound as a light yellow oily substance.

1. customThe reaction liquid
2. concentrationwas concentrated under reduced pressure
3. dissolutiondissolved in ethyl acetate
4. washwashed with an aqueous sodium bicarbonate solution and saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue obtained
8. customwas purified