反应详情

25 g 4-hydrazinocarbonyl-piperidine-1-carboxylic acid tert-butyl ester was refluxed with 125 mL 1,1,1-trimethoxy-2-methyl-propane overnight. The excess of reagent was removed under vacuum and the residue was purified by chromatography on silica gel to give 16 g of the desired product. 1H NMR (400 MHz, MeOD): δ 4.08-4.04 (m, 2H, CH2), 3.20-3.13 (m, 2H, 2CH), 3.01 (br, 2H, CH2), 2.07-2.03 (m, 2H, CH2), 1.75-1.68 (m, 2H, CH2), 1.46 (s, 9H, 3CH3), 1.36 (d, J=6.8 Hz, 6H, 2CH3).

1. customThe excess of reagent was removed under vacuum
2. customthe residue was purified by chromatography on silica gel