Indole-4-carboxaldehyde → 1-(2-Thienylmethyl)indole-4-carbaldehyde

HRID 2394414Notes

Reaction equation

HRID 2394414 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1.CS(O[CH2:17][C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)(=O)=O>>[S:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[CH2:17][N:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 189734302-Thienylmethyl methanesulfonate

Product 1

HCID 189733511-(2-Thienylmethyl)indole-4-carbaldehyde

Procedure

The same procedures used in Example 1 were repeated except for using 725 mg of indole-4-carbaldehyde and 2-thienylmethyl methanesulfonate instead of the benzyl bromide used in Example 1 to give 392 mg of 1-(2-thienylmethyl)indole-4-carbaldehyde as pale yellow crystals. The yield thereof was found to be 33%.

Sources & evidence

ORD record
ord-b94a6aca0ff0439087d60dd97479227e
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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