反应详情

0.2 g of 1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-5-methoxy-3-{1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy}pyrazole was dissolved in 10 mL of chloroform, and 92 mg of m-chloroperbenzoic acid (purity: 75%) was added under cooling with ice. After stirring for one hour under cooling with ice, the solution was washed with an aqueous sodium thiosulfate solution and then washed with an aqueous sodium hydrogen carbonate solution, and then dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure, and the obtained residue was purified by column chromatography (developing solvent ethyl acetate:hexane=1:2) to obtain 0.20 g of 1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl}-5-methoxy-3-{1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy}pyrazole.

1. temperatureunder cooling with ice
2. temperatureunder cooling with ice
3. washthe solution was washed with an aqueous sodium thiosulfate solution
4. washwashed with an aqueous sodium hydrogen carbonate solution
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThen, the solvent was distilled off under reduced pressure
7. customthe obtained residue was purified by column chromatography (developing solvent ethyl acetate:hexane=1:2)