反应详情

The title compound was prepared following the method described above for 2,2′-(2-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-9-(4-carboxyphenyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxamido)ethylazanediyl)diacetic acid (example 88). using 2-bromoethanesulfonic acid as alkylating reagent. The product was isolated as a white solid (3 mg, 39%). LCMS: m/e 709.37 (M+H)+, 2.04 min (method 1). 1H NMR (500 MHz, Acetic Acid-d4) δ ppm 8.03 (d, J=8.54 Hz, 2H), 7.30 (d, J=8.24 Hz, 2H), 5.37 (d, J=6.10 Hz, 1H), 4.79 (s, 1H), 4.66 (s, 1H), 3.93-3.75 (m, 2H), 3.74-3.62 (m, 2H), 3.50-3.44 (m, 2H), 3.42 (t, J=5.80 Hz, 2H), 3.20-3.06 (m, 1H), 2.66-2.47 (m, 1H), 1.75 (s, 3H), 2.31-1.10 (m, 21H), 1.09 (s, 3H), 1.06 (s, 3H), 1.06 (s, 3H), 1.01 (s, 3H), 0.99 (s, 3H).