反应详情

A flask charged with 5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1″-tert-butoxycarbonyl-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (50 mg), 10% palladium on carbon (5 mg), and methanol (5 mL) is shaken under H2 atmosphere (1 bar) at room temperature for 2 h. The catalyst is separated by filtration and the filtrate is concentrated to give the title compound. LC (method 3): tR=0.93 min; Mass spectrum (ESI+): m/z=492 [M+H]+.

1. customThe catalyst is separated by filtration
2. concentrationthe filtrate is concentrated