反应详情

[Methoxy(tetrahydro-4H-pyran-4-ylidene)methoxy](trimethyl)silane (2.2 g, 10.0 mmol, EXAMPLE 1, step 3) was added to the mixture of 4-(benzyloxy)-3-{2-[1-(ethoxymethyl)piperidin-4-yl]ethoxy}-1,2-benzisoxazole (3.4 g, 8.4 mmol, EXAMPLE 7, step 4) and magnesium chloride (40 mg, 0.42 mmol) in acetonitrile (16.0 mL) at ambient temperature. After being stirred at room temperature for 3 h, the mixture was concentrated in vacuo to give an oil. The residual oil was purified by silica gel column chromatography (ethyl acetate/hexane 2:3) to give 3.2 g (75%) of the title compound as a colorless oil.

1. concentrationthe mixture was concentrated in vacuo
2. customto give an oil
3. customThe residual oil was purified by silica gel column chromatography (ethyl acetate/hexane 2:3)