反应详情

A solution of methyl 7-(benzyloxy)-2-bromo-5H-pyrido[3,2-b]indole-4-carboxylate (25 mg, 0.061 mmol) in TFA (0.5 mL) was heated at 80° C. for 20 min. The solvent was removed to leave a solid. This was suspended in a mixture of EtOAc and hexane and the solid was collected by filtration to give methyl 2-bromo-7-hydroxy-5H-pyrido[3,2-b]indole-4-carboxylate (10 mg, 0.031 mmol, 51% yield). MS (ESI) m/z 320.9 (M+H). 1H NMR (400 MHz, MeOD) δ ppm 8.03 (1H, d, J=8.56 Hz), 7.79 (1H, s), 6.99 (1H, d, J=1.76 Hz), 6.79 (1H, dd, J=8.56, 2.27 Hz), 4.00-4.07 (3H, m).

1. customThe solvent was removed
2. customto leave a solid
3. filtrationthe solid was collected by filtration