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HRID241128

反应详情

EQUATION

反应方程式

HRID 241128 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)CCc2ncnc(N3CCOc4ccc(B(O)O)cc4C3)c2C1
HCID66820411

未命名化合物

结构：CN1CC[C@H](CNS(=O)(=O)c2cc(Br)cnc2N)C1
HCID68778576

未命名化合物

PRODUCTS

生成物

1
结构：CN1CC[C@H](CNS(=O)(=O)c2cc(-c3ccc4c(c3)CN(c3ncnc5c3CC(C)(C)CC5)CCO4)cnc2N)C1
HCID59586583

未命名化合物

PROCEDURE

实验过程

Prepared according to the method of example 5 by using 2-amino-5-bromo-N-{[(3S)-1-methylpyrrolidin-3-yl]methyl}pyridine-3-sulfonamide (reagent preparation 25) and [4-(6,6-dimethyl-5,6,7,8-tetrahydroquinazolin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]boronic acid (reagent preparation 23) in step 1. 1H NMR (400 MHz, Methanol-d4): 8.44 (br, 1H), 8.34 (s, 1H), 8.17 (s, 1H), 7.50 (s, 1H), 7.40 (d, 1H), 7.05 (d, 1H), 4.70 (s, 2H), 4.31 (m, 2H), 3.97 (m, 2H), 3.16 (m, 1H), 3.04 (t, 2H), 2.94 (d, 2H), 2.67 (t, 2H), 2.67 (s, 3H), 2.47 (s, 2H), 2.52 (m, 1H), 2.10 (m, 1H), 1.90 (m, 1H), 1.65 (m, 3H), 0.92 (s, 6H); MS (EI) for C29H37N7O3S: 564 (MH+).

WORKUP

后处理

  1. customPrepared