2-methylpropyl 2-methyl-6-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-1H-imidazo[4,5-b]pyridine-1-carboxylate → HCID 178437671, compound

HRID 241155Notes

Reaction equation

HRID 241155 reaction equation
[CH3:1][C:2]1[N:3](C(OCC(C)C)=O)[C:4]2[C:5]([N:21]=1)=[N:6][CH:7]=[C:8]([C:10]1[CH:11]=[CH:12][C:13]3[O:19][CH2:18][CH2:17][NH:16][CH2:15][C:14]=3[CH:20]=1)[CH:9]=2.Cl[C:30]1[C:35]([CH3:36])=[C:34]([CH2:37][CH3:38])[N:33]=[C:32]([CH2:39][N:40]([CH3:42])[CH3:41])[N:31]=1>>[CH2:37]([C:34]1[C:35]([CH3:36])=[C:30]([N:16]2[CH2:15][C:14]3[CH:20]=[C:10]([C:8]4[CH:9]=[C:4]5[N:3]=[C:2]([CH3:1])[NH:21][C:5]5=[N:6][CH:7]=4)[CH:11]=[CH:12][C:13]=3[O:19][CH2:18][CH2:17]2)[N:31]=[C:32]([CH2:39][N:40]([CH3:42])[CH3:41])[N:33]=1)[CH3:38]

Participants

3

Reactant 2

HCID 668204282-methylpropyl 2-methyl-6-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-1H-imidazo[4,5-b]pyridine-1-carboxylateHCID 790775911-(4-chloro-6-ethyl-5-methylpyrimidin-2-yl)-N,N-dimethylmethanamine

Product 1

HCID 178437671HCID 178437671, compound

Procedure

Prepared according to the method of example 6 by using 2-methylpropyl 2-methyl-6-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-1H-imidazo[4,5-b]pyridine-1-carboxylate and 1-(4-chloro-6-ethyl-5-methylpyrimidin-2-yl)-N,N-dimethylmethanamine (reagent preparation 17) in step 3. 1H NMR (400 MHz, DMSO-d6) δ 8.51 (br s, 1H), 8.03 (br s, 1H), 7.70 (d, 1H), 7.52 (dd, 1H), 7.03 (d, 1H), 4.61 (s, 2H), 4.33-4.28 (m, 2H), 3.84-3.79 (m, 2H), 3.36 (s, 2H), 2.63 (q, 2H), 2.53 (d, 3H), 2.20 (s, 3H), 2.13 (s, 6H), 1.89 (s, 3H), 1.14 (t, 3H); MS (EI) for C26H31N7O: 458 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a0b696ab703149a19a02bfdd2fb9f73d
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

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