反应详情

Using (4-bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (2.90 g) described in Preparation Example 171 and 5-oxopyrrolidine-3-carboxylic acid methyl ester (1.00 g) and by the reaction and treatment in the same manner as in Example 1, 1-{2-chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid methyl ester (2.80 g) was obtained. The so obtained 1-{2-chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid methyl ester (1.40 g) was dissolved in methanol (6 mL), 1N aqueous sodium hydroxide solution (6 mL) was added, and the mixture was stirred with heating under reflux for 3 hr. The reaction mixture was cooled, neutralized with 1N hydrochloric acid (6 mL), 1-methylpiperazine (0.33 mL) and 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (1.00 g) were added, and the mixture was stirred at room temperature overnight. The solvent was evaporated from the reaction mixture, water was added, and the mixture was extracted with chloroform. The organic layer was washed with water and saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give 1-{2-chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-4-(4-methylpiperazine-1-carbonyl)pyrrolidin-2-one. The obtained 1-{2-chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-4-(4-methylpiperazine-1-carbonyl)pyrrolidin-2-one was dissolved in ethyl acetate, 4N hydrogen chloride/ethyl acetate (0.75 mL) was added, and the precipitate was collected by filtration to give the title compound (0.74 g).