反应详情

1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline (2.72 g, 9.6 mmol) (prepared according to the process as disclosed in WO97/43287, Intermediate 7, page 24) and 2-chloro-5-(4-methoxyphenyl)pyrimidine (1.04 g, 4.78 mmol) were stirred in DMF (20 mL, anhydrous) at 120° C. for 16 h. The resulting mixture was quenched with saturated NH4Cl, extracted with ethyl acetate and dried with MgSO4. The reaction mixture solvent was evaporated and the residue purified by column chromatography (silica gel, ethyl acetate:hexanes=1:2) to yield the product as a white solid.

1. customThe resulting mixture was quenched with saturated NH4Cl
2. extractionextracted with ethyl acetate
3. dry with materialdried with MgSO4
4. customThe reaction mixture solvent was evaporated
5. customthe residue purified by column chromatography (silica gel, ethyl acetate:hexanes=1:2)