反应详情

The 2-[6-(3-fluoro-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid (see example 3) (0.029 g, 0.058 mmol) was diluted in tetrahydrofuran (0.5 mL) and borane-methyl sulfide complex was added (0.017 mL, 0.175 mmol) at −20° C. The mixture was stirred 2 h from −20° C. to room temperature. Methanol was added and the solvents evaporated under vacuum. The resulting solid formed was purified by chromatography (SiO2, CH2Cl2/MeOH 9:1 v:v) to give the title compound as a white solid (0.018 g, 94%). MS: m/e=330.4 (M+H+).

1. additionborane-methyl sulfide complex was added (0.017 mL, 0.175 mmol) at −20° C
2. customthe solvents evaporated under vacuum
3. customThe resulting solid formed
4. customwas purified by chromatography (SiO2, CH2Cl2/MeOH 9:1 v:v)