Hydrochloric Acid → HCID 20315688, 화합물

HRID 2419457노트

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HRID 2419457 반응식
C1(C(C2C=CC=CC=2)C2CCNCC2)C=CC=CC=1.[ClH:20].[Cl:21]CCN1CCCCC1.C(=O)([O-])[O-].[Na+].[Na+].[N:36]1([CH2:42][CH2:43][N:44]2[CH2:49][CH2:48][CH:47]([CH:50]([C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=3)[C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)[CH2:46][CH2:45]2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1.Cl>C(O)C>[ClH:21].[ClH:20].[N:36]1([CH2:42][CH2:43][N:44]2[CH2:49][CH2:48][CH:47]([CH:50]([C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)[C:57]3[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=3)[CH2:46][CH2:45]2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 882784-BenzhydrylpiperidineHCID 203156891-(2-Piperidinoethyl)-4-(diphenylmethyl)piperidine

생성물 1

HCID 20315688HCID 20315688, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Following Scheme I, 18.1 parts of 4-diphenylmethylpiperidine (U.S. Pat. No. 3,806,526) 13.6 parts of 2-chloroethylpiperidine hydrochloride and 16 parts of sodium carbonate are placed in 250 parts of aqueous 95% ethanol and heated at reflux for 5 hours with stirring. The ethanol is removed to provide an oil which is 1-(2-piperidinoethyl)-4-(diphenylmethyl)piperidine. This oil is dissolved in anhydrous ethanol and 2 equivalents of hydrochloric acid gas are added to provide 1-(2-piperidinoethyl)-4-(diphenylmethyl)piperidine dihydrochloride, melting at 330° C. The anhydrous ethanol solution of 1-(2-piperidinoethyl)-4-(diphenylmethyl)piperidine is reacted with 1.5 equivalents of oxalic acid to provide the oxalic acid salt. In a similar manner other previously mentioned pharmaceutically acceptable salts are formed.

후처리

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. customThe ethanol is removed
  4. customto provide an oil which

출처 및 근거

ORD 기록
ord-dd096a6207734e7b9b1dcffdf792d7c1
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04105849

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