反应详情

1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (50 mg, 0.18 mmol, synthesized in accordance with WO2004/108683), 5-hydrazinocarbonylthiophene-2-carboxylic acid 2-propylamide (40 mg, 0.18 mmol) prepared in Reference Synthetic Example 3 and p-toluenesulfonic acid (6 mg) were heated with 2-propanol (1.8 mL) for 14 hours with reflux. After cooling, the solvent was evaporated, and the resulting solid was washed with 2-propanol to give 36 mg of the desired product (yield 42%).

1. temperaturewith reflux
2. temperatureAfter cooling
3. customthe solvent was evaporated
4. washthe resulting solid was washed with 2-propanol