反应详情

1-(5′-Chloro-3-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine was prepared in a similar manner to 1-(2-allyl-5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine (Example 34) using 1-(4-bromo-2-chloro-phenyl)-ethylamine instead of 1-(4-bromo-2-fluoro-phenyl)-ethylamine and 5-chloro-2-methoxyphenyl boronic acid instead of 5-fluoro-2-methoxyphenyl boronic acid. The title compound was prepared in a similar manner to 1-methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonic acid [1-(3,5′-difluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 30) using 1-(5′-chloro-3-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine and 3,4-di-fluorophenyl sulfonyl chloride instead of 1-methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonyl chloride. 1H NMR (400 MHz, CDCl3): δ 7.55-7.41 (m, 2H), 7.28 (q, 1H), 7.17 (d, 1H), 7.12-6.99 (m, 4H), 6.89 (d, 1H), 5.16 (d, 1H), 4.73 (dq, 1H), 3.80 (s, 3H), 1.55 (d, 3H) ppm; MS (ESI) m/z: 478.0 [M+Na]+.