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HRID242456

反应详情

EQUATION

反应方程式

HRID 242456 的结构方程式

REACTANTS

反应物

3
结构：CNC(=O)[C@@H](NC(=O)n1nc(-c2cc(F)c(F)cc2F)c2c1CCN(C)C2)C(C)(C)C
HCID46863441

未命名化合物

结构：CC(C)(C)OC(=O)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1
HCID59345327

未命名化合物

结构：CC(C)(C)OC(=O)N1CCc2[nH]nc(-c3ccc(C(F)(F)F)cc3F)c2C1
HCID66997625

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)[C@@H](NC(=O)n1nc(-c2ccc(C(F)(F)F)cc2F)c2c1CCN(C)C2)C(C)(C)C
HCID46862471

未命名化合物

PROCEDURE

实验过程

Compound 43 was prepared according to the procedure described for the synthesis of compound 37 by replacing intermediate 19 with tert-butyl 3-(2-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate, which was prepared according to the procedure described for the synthesis of intermediate 15 by replacing 3,4-difluorobenzoyl chloride with 2-fluoro-4-trifluoro-benzoyl chloride. 1H NMR (CDCl3) δ 7.92 (d, J=9.4 Hz, 1H), 7.83 (t, J=7.5 Hz, 1H), 7.50 (d, J=7.5 Hz, 1H), 7.42 (d, J=10.3 Hz, 1H), 6.17 (br, 1H), 4.17 (d, J=9.5 Hz, 1H), 3.52 (s, 2H), 3.21-3.28 (m, 2H), 2.79-2.89 (m, 5H), 2.51 (s, 3H), 1.08 (s, 9H). LCMS (+ESI) m/z=470 [M+H]+.

WORKUP

后处理

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