HCID 67180429, compound → 1-(5-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanamine dihydrochloride

HRID 2425545Notes

Reaction equation

HRID 2425545 reaction equation
[ClH:1].Cl.[CH3:3][N:4]1[C:8]([CH3:9])=[C:7]([C@H:10]([NH2:12])[CH3:11])[CH:6]=[N:5]1.CC1N(C[C:20]([F:23])([F:22])[F:21])N=CC=1C(=O)C>>[ClH:1].[ClH:1].[CH3:9][C:8]1[N:4]([CH2:3][C:20]([F:23])([F:22])[F:21])[N:5]=[CH:6][C:7]=1[CH:10]([NH2:12])[CH3:11]

Participants

3

Reactant 2

HCID 67180429HCID 67180429, compoundHCID 671822581-(5-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanone

Product 1

HCID 671832121-(5-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanamine dihydrochlorideYield 99%

Procedure

The title compound was prepared in >99% yield by the same process as described for (R)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethanamine dihydrochloride (Amine 2) using 1-(5-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanone (Step A6A) as a starting material. 1H NMR (300 MHz, DMSO-d6) δ 1.49 (3H, d, J=6.0 Hz), 2.32 (3H, s), 4.29-4.33 (1H, m), 5.07 (1H, d, J=9.0 Hz), 5.13 (1H, d, J=9.0 Hz), 7.72 (1H, s), 8.34 (3H, brs).

Sources & evidence

ORD record
ord-09bfe4e0c8324e11993ca8283bc30a3b
Source dataset
uspto-grants-2011_06
Patent number
US07964732B2

Reaction notes

Loading…