HCID 67180429, compound → Methyl 2-(4-(1-aminoethyl)-5-methyl-1H-pyrazol-1-yl)acetate dihydrochloride

HRID 2425548Notes

Reaction equation

HRID 2425548 reaction equation
[ClH:1].Cl.[CH3:3][N:4]1[C:8]([CH3:9])=[C:7]([C@H:10]([NH2:12])[CH3:11])[CH:6]=[N:5]1.C(C1C=NN(C[C:23]([O:25][CH3:26])=[O:24])C=1C)(=O)C>>[ClH:1].[ClH:1].[NH2:12][CH:10]([C:7]1[CH:6]=[N:5][N:4]([CH2:3][C:23]([O:25][CH3:26])=[O:24])[C:8]=1[CH3:9])[CH3:11]

Participants

3

Reactant 2

HCID 67180429HCID 67180429, compoundHCID 67181907Methyl 2-(4-acetyl-5-methyl-1H-pyrazol-1-yl)acetate

Product 1

HCID 67181378Methyl 2-(4-(1-aminoethyl)-5-methyl-1H-pyrazol-1-yl)acetate dihydrochlorideYield 6.6%

Procedure

The title compound was prepared in 6.6% yield by the process as described for (R)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethanamine dihydrochloride (Amine 2) using methyl 2-(4-acetyl-5-methyl-1H-pyrazol-1-yl)acetate (Step A8A) as a starting material. 1H NMR (300 MHz, DMSO-d5) δ 1.48 (3H, d, J=6.0 Hz), 2.22 (3H, s), 3.69 (3H, s), 4.29-4.33 (1H, m), 5.05 (2H, s), 7.59 (1H, s), 8.26 (3H, brs).

Sources & evidence

ORD record
ord-72e19205a5a14bc5b43cdfcd270bcfd3
Source dataset
uspto-grants-2011_06
Patent number
US07964732B2

Reaction notes

Loading…