反应详情

3-(3-Dimethylaminopropyl)-2-formyl-4,5,6,7-tetrahydro-1H-indole (1.8 g), 1 g of 2-oxindole and 0.1 g of piperidine in 10 mL of ethanol was refluxed for 4 hours and then cooled to room temperature. The precipitate which formed was collected by vacuum filtration and washed with 4 mL of ethanol. The solids were slurry-washed with 8 mL of refluxing ethanol, cooled, collected by vacuum filtration, washed with 3 mL of ethanol and vacuum dried to give 1.8 g (70% yield) of 3-[3-(3-dimethylaminopropyl)-4,5,6,7-tetrahydro-1H-indol-2-ylmethylene]-1,3-dihydroindol-2-one as an orange solid.

1. customThe precipitate which formed
2. filtrationwas collected by vacuum filtration
3. washwashed with 4 mL of ethanol
4. washThe solids were slurry-washed with 8 mL of refluxing ethanol
5. temperaturecooled
6. filtrationcollected by vacuum filtration
7. washwashed with 3 mL of ethanol and vacuum
8. customdried