反应详情

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine (81 mg, 0.25 mmol) was dissolved in THF (3 ml) to which was subsequently added 10% hydrochloric acid (2 ml) at room temperature. After 1 hour of stirring at the same temperature, the solvent was removed by evaporation, and the resulting residue was subjected to azeotropic distillation using benzene (5 ml×4) to obtain an orange glutinous material. The thus obtained residue was dissolved in methanol (2 ml) to which were subsequently added o-anisidine (29 μl, 0.25 mmol) and sodium cyanoborohydride (11 mg, 0.166 mmol) at room temperature. After 2 hours of stirring at the same temperature, the reaction solution was mixed with saturated sodium carbonate aqueous solution (10 ml), extracted with ethyl acetate and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous sodium carbonate, the solvent was removed by evaporation and then the resulting residue was purified by subjecting it to a silica gel column chromatography (ether:hexane=2:1-ether) to obtain 59 mg (66.2%) of the title compound in the form of colorless solid.

1. customat room temperature
2. customthe solvent was removed by evaporation
3. distillationthe resulting residue was subjected to azeotropic distillation
4. customto obtain an orange glutinous material
5. customat room temperature
6. stirringAfter 2 hours of stirring at the same temperature
7. extractionextracted with ethyl acetate
8. washwashed with water and saturated brine
9. dry with materialThe resulting organic layer was dried on anhydrous sodium carbonate
10. customthe solvent was removed by evaporation
11. customthe resulting residue was purified