反应详情

59.7 mg (0.109 mmol) of ethyl [6-(3-chlorophenyl)-5-(3,3-diphenylpropylcarbamoyl)-4-methyl-2-oxo-3,6-dihydro-2H-pyrimidine-1-yl]acetate was dissolved in 10 ml of methanol. 0.219 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution at room temperature, and they were stirred for 12 hours. 1 N hydrochloric acid was added to the reaction mixture. Methanol was evaporated under reduced pressure. Water was added to the residue, and precipitates thus formed were taken by the filtration, then washed with hexane/ethyl acetate (3/1) and dried under reduced pressure to obtain the title compound.

1. customMethanol was evaporated under reduced pressure
2. additionWater was added to the residue
3. customprecipitates thus
4. customformed
5. filtrationwere taken by the filtration
6. washwashed with hexane/ethyl acetate (3/1)
7. customdried under reduced pressure